HYOU1 inhibitor 33

Chemical Structure : HYOU1 inhibitor 33

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货号: PC-21758Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

HYOU1 inhibitor 33 is a first-in-class inhibitor for Hypoxia up-regulated protein 1 (HYOU1, GRP170/ORP150), decreases significantly the levels of the cytokine Interleukin 6 (IL-6) in LPS (10 ng/mL)-treated WT-MΦs with IC50 of 2.57 uM.
HYOU1 inhibitor 33 downregulates the expression of Mmp3 and Bmp2 genes, both being highly upregulated in activated fibroblasts promoting chronic inflammation and fibrosis.
HYOU1 inhibitor 33 inhibits multiple pathways found activated in pathogenic fibroblasts, including extracellular matrisome alteration, TNFsignaling, cytokine/chemokine production and collagen fibril organization.

物理化学性质&存储条件

分子量	436.38
分子式	C22H27Cl2N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-amino-5-chloro-N-((1-((4-chlorophenyl)amino)cycloheptyl)methyl)-2-methoxybenzamide

参考文献

1. Papadopoulou D, et al. Angew Chem Int Ed Engl. 2024 Feb 10:e202319157.