HXJ 42 |CAS:1428640-39-4 Probechem Biochemicals

Chemical Structure : HXJ 42

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HXJ 42 (HXJ42)

货号: PC-70328Not For Human Use, Lab Use Only.

HXJ 42 is a PP1 analog that has greater selectivity and potency for Zap-70(AS) over wild-type Zap-70, as assessed by Erk and Lat phosphorylation, as well as by proliferative responses of mature CD4+ cells.

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生物&药学活性

HXJ 42 is a PP1 analog that has greater selectivity and potency for Zap-70(AS) over wild-type Zap-70, as assessed by Erk and Lat phosphorylation, as well as by proliferative responses of mature CD4+ cells.
HXJ 42 effectively rescues Zap70(AS) OT-I cells from negative selection.

物理化学性质&存储条件

分子量	352.219
分子式	C15H15Cl2N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)(2,3-dichlorophenyl)methanol

参考文献

1. Au-Yeung BB, et al. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3679-88.

2. Au-Yeung BB, et al. Nat Immunol. 2014 Jul;15(7):687-94.

HXJ 42 (HXJ42)

生物&药学活性

物理化学性质&存储条件

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HXJ 42 (HXJ42)

生物&药学活性

物理化学性质&存储条件

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