HX600 |CAS:172705-89-4 Probechem Biochemicals

Chemical Structure : HX600

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HX600 (HX-600;HX 600)

货号: PC-35535Not For Human Use, Lab Use Only.

HX600 (HX-600) is a synthetic agonist of RXR-Nurr1 heterodimer complex, also selectively activate NGFI-B/RXR heterodimers.

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1 g		Get quote

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生物&药学活性

HX600 (HX-600) is a synthetic agonist of RXR-Nurr1 heterodimer complex, also selectively activate NGFI-B/RXR heterodimers.
HX600 effectively induces only carnitine palmitoyltransferase 1A (CPT1A) in human teratocarcinoma NT2/D1 cells, which express RXRα, Nur77 and NURR1.
HX600 also increases CPT1A expression in human embryonic kidney (HEK) 293 cells and hepatocyte-derived HepG2 cells.
HX600 reduces microglia expressed proinflammatory mediators and prevents inflammation induced neuronal death in in vitro co-culture model of neurons and microglia, prevents ischemia-induced neuronal damage in vivo.

物理化学性质&存储条件

分子量	438.571
分子式	C29H30N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(5,7,7,10,10-pentamethyl-7,8,9,10-tetrahydro-5H-benzo[b]naphtho[2,3-e][1,4]diazepin-12-yl)benzoic acid

参考文献

1. Loppi S, et al. Brain Behav Immun. 2018 Jul 29. pii: S0889-1591(18)30368-4.

2. Ishizawa M, et al. Biochem Biophys Res Commun. 2012 Feb 24;418(4):780-5.

3. Morita K, et al. Biochem Pharmacol. 2005 Dec 19;71(1-2):98-107.

HX600 (HX-600;HX 600)

生物&药学活性

物理化学性质&存储条件

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HX600 (HX-600;HX 600)

生物&药学活性

物理化学性质&存储条件

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