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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-RAR/RXR-HX531
HX531

Chemical Structure : HX531

CAS No.: 188844-34-0

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HX531 (HX 531)

货号: PC-20776Not For Human Use, Lab Use Only.

HX531 is a potent, pan RXR antagonist with IC50 of 18 nM on retinoidal activity in HL-60 cell assays, HX531 also is a partial PPARγ inhibitor and ameliorates diet-induced obesity and type 2 diabetes.

规格 价格 库存 数量
10 mg ￥1980 In stock
25 mg ￥3480 In stock
50 mg ￥5880 In stock
100 mg Get quote
1 g Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

HX531 is a potent, pan RXR antagonist with IC50 of 18 nM on retinoidal activity in HL-60 cell assays, HX531 also is a partial PPARγ inhibitor and ameliorates diet-induced obesity and type 2 diabetes.

物理化学性质&存储条件

分子量 483.57
分子式 C29H29N3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(O)C1=CC=C(C2=NC3=CC([N+]([O-])=O)=CC=C3N(C)C4=CC5=C(C(C)(C)CCC5(C)C)C=C42)C=C1

参考文献

1. M Ebisawa, et al. Chem Pharm Bull (Tokyo). 1999 Dec;47(12):1778-86.

2. T Yamauchi, et al. J Clin Invest. 2001 Oct;108(7):1001-13.

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