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首页-小分子抑制剂&激动剂-GPCR-Free Fatty Acid Receptor (FFAR)-HWL-088
HWL-088

Chemical Structure : HWL-088

CAS No.: 2378617-96-8

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HWL-088 (HWL088)

货号: PC-24882Not For Human Use, Lab Use Only.

HWL-088 is a potent, selective and orally active FFAR1 (FFA1, GPR40) agonist with EC50 of 19 nM, has moderate PPARδ activity (EC50=570.9 nM).

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5 mg ￥1580 In stock
10 mg ￥2480 In stock
25 mg ￥4280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

HWL-088 is a potent, selective and orally active FFAR1 (FFA1, GPR40) agonist with EC50 of 19 nM, has moderate PPARδ activity (EC50=570.9 nM).
HWL-088 has no agonist activity on PPARα and PPARγ.
HWL-088 (3 uM) exhibits glucose‐dependent insulinotropic effects in MIN6 cells.
HWL-088 promotes glucose‐dependent insulin secretion in vitro and in vivo.

物理化学性质&存储条件

分子量 366.39
分子式 C22H19FO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(2-fluoro-4-((2'-methyl-[1,1'- biphenyl]-3-yl)methoxy)phenoxy)acetic acid

参考文献

1. Li Z, et al. Bioorg Chem. 2019 Nov;92:103209.

2. Chen Y, et al. Br J Pharmacol. 2020 May;177(10):2286-2302.

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