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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Sphingosine kinase (SphK)-HWG-35D
HWG-35D

Chemical Structure : HWG-35D

CAS No.: 2345640-02-8

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HWG-35D

货号: PC-49708Not For Human Use, Lab Use Only.

HWG-35D is a potent, selective sphingosine kinase 2 (SphK2, SK2) with IC50 of 41 nM, 100-fold selectivity for SK2 over SK1.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    HWG-35D is a potent, selective sphingosine kinase 2 (SphK2, SK2) with IC50 of 41 nM, 100-fold selectivity for SK2 over SK1.
    HWG-35D (0-500 nM) did not alter either SK1 or dihydroceramide desaturase 1 (DES1) protein expression in either human or murine cells, HWG-35D (300 nM) did not decrease SK1 protein levels in total CD4+ T cells isolated from mouse spleen.
    HWG-35D topical application reduced psoriasis-like skin symptoms induced by imiquimod (IMQ), normalized the serum interleukin-17A levels elevated by IMQ.
    HWG-35D also decreased skin mRNA levels of interleukin-17A, K6 and K16 genes induced by IMQ, blocked T helper type 17 differentiation of naïve CD4+ T cells with concomitant reduction of SOCS1.
    HWG-35D dose-dependently increased Smad7 expression and ameliorated the expression of Col1, FN-1 and CTGF in primary renal fibroblasts.
    HWG-35D demonstrated anti-fibrotic potential in unilateral ureter obstruction (UUO), a model for progressive renal fibrosis.

    物理化学性质&存储条件

    分子量 437.96
    分子式 C26H28ClNO3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-(1-(4-((3-((4-Chlorobenzyl)oxy)phenoxy)methyl)benzyl)pyrrolidin-2-yl)methanol

    参考文献

    1. Adams D.R., et al. J Med. Chem. 2019;62:3658–3676.

    2. Shin SH, et al. Cell Signal. 2021 Mar;79:109881.

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