HW201877 | 15-PGDH inhibitor | Probechem Biochemicals

Chemical Structure : HW201877

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HW201877 (HW-201877)

货号: PC-24859Not For Human Use, Lab Use Only.

HW201877 is a potent, selective and orally active 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor with IC50 of 3.6 nM.

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生物&药学活性

HW201877 is a potent, selective and orally active 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor with IC50 of 3.6 nM.
HW201877 exhibits robust cellular efficacy in elevating PGE2 levels in A549 cells (4.8-fold increase vs control).
HW201877 (0.5, 1.0, or 2.0 mg/kg, BID) marked reductions in pulmonary fibrosis scores, achieving comparable therapeutic efficacy in a bleomycin-induced rat pulmonary fibrosis model.

物理化学性质&存储条件

分子量	440.45
分子式	C22H22F2N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	7-[(1aS,7bR)-6-(4,4-difluoropiperidine-1-carbonyl)-1,1a,2,7b-tetrahydro-3H-cyclopropa[c][1,8]naphthyridin-3-yl]-2-methyl[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

参考文献

1. Qun Li, et al. J Med Chem. 2025 Jun 26. doi: 10.1021/acs.jmedchem.5c01361.

HW201877 (HW-201877)

生物&药学活性

物理化学性质&存储条件

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HW201877 (HW-201877)

生物&药学活性

物理化学性质&存储条件

参考文献

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