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首页-小分子抑制剂&激动剂-Others-AP2-associated Kinase 1 (AAK1)-HW161023
HW161023

Chemical Structure : HW161023

CAS No.: 2920698-73-1

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HW161023

货号: PC-23576Not For Human Use, Lab Use Only.

HW161023 is a potent, selective AAK1 inhibitor with IC50 of 5.4 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

HW161023 is a potent, selective AAK1 inhibitor with IC50 of 5.4 nM.
HW161023 shows high selectivity in 225 kinase panel.
HW161023 (10 mg/kg; p.o.) reduced mechanical hyperalgesia in CCI rats.

物理化学性质&存储条件

分子量 374.44
分子式 C20H24F2N4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-1-((8-(2-(difluoromethyl)pyridin-4-yl)imidazo[1,2-a]pyridin-5-yl)oxy)-2,4-dimethylpentan-2-amine

参考文献

1. Jinping Li, et al. Bioorg Med Chem Lett. 2024 Dec 1:114:130012.

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