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首页-小分子抑制剂&激动剂-GPCR-Cannabinoid Receptor-HU-910
HU-910

Chemical Structure : HU-910

CAS No.: 1309372-84-6

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HU-910 (HU910)

货号: PC-22233Not For Human Use, Lab Use Only.

HU-910 is a potent, selective cannabinoid CB2 receptor agonist with Ki of 6 nM in competition binding assay, IC50 of 162 nM in cAMP assay.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

HU-910 is a potent, selective cannabinoid CB2 receptor agonist with Ki of 6 nM in competition binding assay, IC50 of 162 nM in cAMP assay.
HU-910 displays >250-fold selectivity over CB1 receptor.
HU-910 attenuates the TNFα-induced adhesion molecules expression in human liver sinusoidal endothelial cells (HLSEC).
HU-910 attenuates hepatic ischaemia/reperfusion (I/R) injury.

物理化学性质&存储条件

分子量 414.63
分子式 C27H42O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

((1S,4R)-2-(2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl)-7,7-dimethylbicyclo[2.2.1]hept-2-en-1-yl)methanol

参考文献

1. Horváth B, et al. Br J Pharmacol. 2012 Apr;165(8):2462-78.

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