HU-308 | CB2 agonist | Probechem Biochemicals

Chemical Structure : HU-308

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HU-308 (HU308)

货号: PC-22234Not For Human Use, Lab Use Only.

HU-308 is a potent, selective cannabinoid CB2 receptor agonist with Ki of 22.7 nM in competition binding assay, does not bind to CB1 receptor.

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生物&药学活性

HU-308 is a potent, selective cannabinoid CB2 receptor agonist with Ki of 22.7 nM in competition binding assay, does not bind to CB1 receptor.
HU-308 inhibits forskolin-stimulated cyclic AMP production in CB(2)-transfected cells, but does so much less in CB(1)-transfected cells.
HU-308 has IC50 of 117 nM in cAMP assays, EC50 of 18.3 nM in [35S]GTPγS binding assays.
HU-308 reduces blood pressure, blocks defecation, and elicits anti-inflammatory and peripheral analgesic activity in mice in a tetrad of behavioral tests.

物理化学性质&存储条件

分子量	414.62
分子式	C27H42O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[4-(1,1-dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethyl-bicyclo[3.1.1]hept-2-ene-2-methanol

参考文献

1. Hanus L, et al. Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14228-33.

2. Ueda Y, et al. Eur J Pharmacol. 2005 Sep 27;520(1-3):164-71.

3. Horváth B, et al. Br J Pharmacol. 2012 Apr;165(8):2462-78.

HU-308 (HU308)

生物&药学活性

物理化学性质&存储条件

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HU-308 (HU308)

生物&药学活性

物理化学性质&存储条件

参考文献

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