HU-210 | NMDAR antagonist | Probechem Biochemicals

Chemical Structure : HU-210

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HU-210 (HU210)

货号: PC-22159Not For Human Use, Lab Use Only.

HU-211 is a functional N-methyl-D-aspartate receptor blocker with IC50 of 6-10 uM for glutamate- or glycine-induced binding.

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100 mg		Get quote

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生物&药学活性

HU-211 is a functional N-methyl-D-aspartate receptor blocker with IC50 of 6-10 uM for glutamate- or glycine-induced binding.
HU-211 is a synthetic terpene-based cannabinoid devoid of central cannabinoid (CB1) and peripheral cannabinoid (CB2) agonist activity.
HU-211 also has anti-inflammatory properties derived through inhibition of NF-κB and the resulting decreases in cytokines such as TNF-α and interleukin-6.
HU-211 induces stereotype and locomotor hyperactivity in mice and tachycardia in rat, effects typically caused by NMDA receptor antagonists.
HU-211 is also a potent blocker of NMDA-induced tremor, seizures, and lethality in mice.

物理化学性质&存储条件

分子量	386.58
分子式	C25H38O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(6aS,10aS)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol

参考文献

1. Feigenbaum JJ, et al. Eur J Pharmacol. 1989 Oct 4;169(1):159-65.

2. Shohami E, et al. J Neurotrauma. 1993 Summer;10(2):109-19.

3. Feigenbaum JJ, et al. Proc Natl Acad Sci U S A. 1989 Dec;86(23):9584-7.

HU-210 (HU210)

生物&药学活性

物理化学性质&存储条件

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HU-210 (HU210)

生物&药学活性

物理化学性质&存储条件

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