HTL0039732 | EP4 antagonist | Probechem Biochemicals

Chemical Structure : HTL0039732

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HTL0039732 (HTL-0039732)

货号: PC-27537Not For Human Use, Lab Use Only.

HTL0039732 is a potent, selective and orally bioavailable E-type prostanoid receptor 4 (EP4) antagonist, blocks signalling through prostaglandin E2 receptor EP4, enhances immune response against tumours that typically resist current immunotherapies.

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生物&药学活性

HTL0039732 is a potent, selective and orally bioavailable E-type prostanoid receptor 4 (EP4) antagonist, blocks signalling through prostaglandin E2 receptor EP4, enhances immune response against tumours that typically resist current immunotherapies.

物理化学性质&存储条件

分子量	435.44
分子式	C23H24F3NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzoic acid, 4-[1-[[(2R)-3-methyl-1-oxo-2-[[4-(trifluoromethyl)phenyl]methoxy]butyl]amino]cyclopropyl]-

参考文献

1. Astley D, et al. Bioanalysis. 2026 Aug 6:1-10. doi: 10.1080/17576180.2026.2712785.

2. Dan Astley, et al. Cancer Res (2026) 86 (8_Supplement): LB469.

3. Patent WO2021069927 A1 2021-04-15.

HTL0039732 (HTL-0039732)

生物&药学活性

物理化学性质&存储条件

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HTL0039732 (HTL-0039732)

生物&药学活性

物理化学性质&存储条件

参考文献

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