HTH-01-015 | NUAK1 inhibitor | Probechem Biochemicals

Chemical Structure : HTH-01-015

CAS No.: 1613724-42-7

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HTH-01-015 (HTH 01 015, HTH-01-15)

货号: PC-42982Not For Human Use, Lab Use Only.

HTH-01-015 is a potent, specific NUAK1 (AMPK-related kinase 5, ARK5) inhibitor with IC50 of 100 nM, displays >100-fold higher potency than NUAK2.

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25 mg	￥1580	In stock
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生物&药学活性

HTH-01-015 is a potent, specific NUAK1 (AMPK-related kinase 5, ARK5) inhibitor with IC50 of 100 nM, displays >100-fold higher potency than NUAK2.
HTH-01-015 also does not markedly suppress the activity of any of the other 139 protein kinases, including AMPK.
HTH-01-015 suppresses NUAK1-mediated MYPT1 phosphorylation in vivo, the NUAK1 mutation (A195T) renders resistant to HTH-01-015.
HTH-01-015 significantly inhibits migration the proliferation of MEFs (mouse embryonic fibroblasts).

物理化学性质&存储条件

分子量	468.5535
分子式	C26H28N8O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6H-Naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one, 5,13-dihydro-4,5,13-trimethyl-2-[[1-(4-piperidinyl)-1H-pyrazol-4-yl]amino]-

参考文献

1. Banerjee S, et al. Biochem J. 2014 Jan 1;457(1):215-25.

2. Banerjee S, et al. Biochem J. 2014 Jul 15;461(2):233-45.

HTH-01-015 (HTH 01 015, HTH-01-15)

生物&药学活性

物理化学性质&存储条件

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HTH-01-015 (HTH 01 015, HTH-01-15)

生物&药学活性

物理化学性质&存储条件

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