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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HIV-HT-7
HT-7

Chemical Structure : HT-7

CAS No.:

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HT-7 (BST2 inducer HT-7)

货号: PC-22959Not For Human Use, Lab Use Only.

HT-7 is a specific, heterocyclic HIV-1 inhibitor inhibits viral release by inducing cell surface bone marrow stromal antigen 2 (BST2)/Tetherin/CD317/HM1.24, increases cell surface BST2 coupled with HIV-1 release reduction in Jurkat cells but not Jurkat/KO-BST2 cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

HT-7 is a specific, heterocyclic HIV-1 inhibitor inhibits viral release by inducing cell surface bone marrow stromal antigen 2 (BST2)/Tetherin/CD317/HM1.24, increases cell surface BST2 coupled with HIV-1 release reduction in Jurkat cells but not Jurkat/KO-BST2 cells.
HT-7 does not regulate the cell surface expression of PSGL-1.
HT-7 reduces the viral release by canceling the effects of Vpu, thereby retaining BST2 on the cell surface.
HT-7 inhibits the release of SIVmac239 and SARS-CoV-2 by induction of BST2 on the cell surface.

物理化学性质&存储条件

分子量 413.48
分子式 C25H23N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(4-(2-(naphthalen-2-yl)-2-oxoethyl)piperazine-1-carbonyl)indolin-2-one

参考文献

1. Perpetual Nyame, et al. J Biol Chem. 2024 Aug 20:107701.

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