HT-0712 |CAS:617720-02-2 Probechem Biochemicals

Chemical Structure : HT-0712

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HT-0712 (IPL-455903, HT0712, IPL455903)

货号: PC-63088Not For Human Use, Lab Use Only.

HT-0712 (IPL-455903) is a novel potent, selective PDE4 inhibitor with IC50 of 0.15 uM for PDE4D3, without effect on PDE1B, PDE3A, and PDE10A.

规格	价格	库存	数量
25 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

HT-0712 (IPL-455903) is a novel potent, selective PDE4 inhibitor with IC50 of 0.15 uM for PDE4D3, without effect on PDE1B, PDE3A, and PDE10A.
HT-0712 (IPL-455903) facilitates expression of a CRE-luciferase reporter gene and expression of the CREB target-gene somatostatin in SK-N-MC neuroblastoma cells,.
HT-0712 (IPL-455903) bolishes the long-term memory defect of CBP+/- mice, enhances long-term memory formation in normal young mice at brain concentrations similar to those found to increase CRE-mediated gene expression in hippocampal neurons.

物理化学性质&存储条件

分子量	393.53
分子式	C25H31NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,5S)-5-(3-(cyclopentyloxy)-4-methoxyphenyl)-3-(3-methylbenzyl)piperidin-2-one

参考文献

1. Peters M, et al. Neuropsychopharmacology. 2014 Dec;39(13):2938-48.

2. MacDonald E, et al. Neurorehabil Neural Repair. 2007 Nov-Dec;21(6):486-96.

3. Bourtchouladze R, et al. Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10518-22.

HT-0712 (IPL-455903, HT0712, IPL455903)

生物&药学活性

物理化学性质&存储条件

参考文献

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HT-0712 (IPL-455903, HT0712, IPL455903)

生物&药学活性

物理化学性质&存储条件

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