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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Monoamine Oxidase (MAO)-HT-0411
HT-0411

Chemical Structure : HT-0411

CAS No.: 947539-81-3

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HT-0411 (HT0411)

货号: PC-61488Not For Human Use, Lab Use Only.

HT-0411 is a selective monoamine oxidase B (MAO-B) inhibitor with IC50 of 1.4 uM, with less potency for MT-1 and MT-2.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    HT-0411 is a selective monoamine oxidase B (MAO-B) inhibitor with IC50 of 1.4 uM, with less potency for MT-1 and MT-2.
    HT-0411 causes CREB activation in vitro, improves 24-hour memory in rodents in a contextual fear conditioning model.

    物理化学性质&存储条件

    分子量 303.303
    分子式 C12H12F3N3OS
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N,N-dimethyl-5-(1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)thiophene-2-carboxamide

    参考文献

    1. Kaplan A, et al. ACS Chem Neurosci. 2017 Dec 20;8(12):2746-2758.

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