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首页-小分子抑制剂&激动剂-Tyrosine Kinase-EGFR-HSL119
HSL119

Chemical Structure : HSL119

CAS No.: 2231745-56-3

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HSL119 (HSL 119, HSL-119)

货号: PC-21782Not For Human Use, Lab Use Only.

HSL119 (HSL-119) is a potent and selective hormonally upregulated neu-associated kinase (HUNK) inhibitor, completely inhibits HUNK kinase activity at 1 uM in biochemical assays.

规格 价格 库存 数量
2 mg ￥2780 In stock
5 mg ￥4580 In stock
10 mg ￥7280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

HSL119 (HSL-119) is a potent and selective hormonally upregulated neu-associated kinase (HUNK) inhibitor, completely inhibits HUNK kinase activity at 1 uM in biochemical assays.
HSL119 directly inhibits the activity of HUNK in HER2+ breast cancer cells.
HSL119 (1 uM) completely blocks phosphorylation of the Rubicon S92 phosphorylation site in vitro.
HSL119 inhibits survival of human HER2+ breast cancer cells with IC5o of 1.7 uM (JIMT-1 cell), but not inhibitors of ABL1, FLT3, and RET, JIMT-1 cells are in fact resistant to neratinib.
HSL119 results in gene expression changes equivalent to HUNK shRNA.
HSL119 (30 mg/kg) demonstrates tumor growth in mice implanted with WHIM8 PDX.
HUNK is downstream in the HER2 pathway, HUNK promotes autophagy in HER2+ breast cancer.

物理化学性质&存储条件

分子量 544.58
分子式 C30H27F3N6O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-((8-amino-1,7-naphthyridin-5-yl)ethynyl)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

参考文献

1. Dilday T, et al. Cell Chem Biol. 2024 Jan 25:S2451-9456(24)00037-0.

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