HSK205 | FLT3/haspin inhibitor | Probechem Biochemicals

Chemical Structure : HSK205

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HSK205 (HSK-205)

货号: PC-22196Not For Human Use, Lab Use Only.

HSK205 is potent, dual FLT3/haspin kinase inhibitor, inhibits haspin and FLT3 at 97% and 94% at 50 nM respectively.

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生物&药学活性

HSK205 is potent, dual FLT3/haspin kinase inhibitor, inhibits haspin and FLT3 at 97% and 94% at 50 nM respectively.
HSK205 inhibits the FLT3-ITD and FLT3 D835Y enzyme with IC50 of 0.199 nM and 0.187 nM.
HSK205 could bind to haspin with Kd = 0.55 nM.
HSK205 has remarkable potencies against FLT3-driven AML cell lines, inhibiting proliferation with GI50 values between 2–25 nM.
HSK205 inhibits the phosphorylation of both FLT3 and histone H3 (a haspin target) in cells.

物理化学性质&存储条件

分子量	436.52
分子式	C26H24N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((4-methyl-1H-imidazol-2-yl)methyl)-4-(8,9,10,11-tetrahydro-3H-pyrazolo[4,3-a]phenanthridin-7-yl)benzamide

参考文献

1. Allison L Kempen, et al. RSC Med Chem. 2023 Jul 14;14(9):1743-1754.

HSK205 (HSK-205)

生物&药学活性

物理化学性质&存储条件

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HSK205 (HSK-205)

生物&药学活性

物理化学性质&存储条件

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