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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-SGLT-HSK0935
HSK0935

Chemical Structure : HSK0935

CAS No.: 1638851-44-1

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HSK0935 (HSK-0935, HSK 0935)

货号: PC-61130Not For Human Use, Lab Use Only.

HSK0935 is a potent and highly selective SGLT2 inhibitor with IC50 of 1.3 nM, >800-fold selectivity over SGLT1 (IC50>1 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    HSK0935 is a potent and highly selective SGLT2 inhibitor with IC50 of 1.3 nM, >800-fold selectivity over SGLT1 (IC50>1 uM).
    HSK0935 shows robust urinary glucose excretion in Sprague-Dawley (SD) rats and affects more urinary glucose excretion in Rhesus monkeys.

    物理化学性质&存储条件

    分子量 436.885
    分子式 C22H25ClO7
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1S,2S,3R,4R,5S)-5-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-1-methoxy-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol

    参考文献

    1. Li Y, et al. J Med Chem. 2017 May 25;60(10):4173-4184.

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