HSF1A | HSF1 activator | Probechem Biochemicals

Chemical Structure : HSF1A

CAS No.: 1196723-93-9

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HSF1A (HSF1 activator)

货号: PC-61302Not For Human Use, Lab Use Only.

HSF1A is a small molecule human HSF1 (heat shock transcription factor 1) activator, also interacts with components of the TRiC/CCT complex.

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

HSF1A is a small molecule human HSF1 (heat shock transcription factor 1) activator, also interacts with components of the TRiC/CCT complex.
HSF1A activates HSF1 in mammalian and fly cells, elevates protein chaperone expression, ameliorates protein misfolding and cell death in polyQ-expressing neuronal precursor cells.
HSF1A protects against cytotoxicity in a fly model of polyQ-mediated neurodegeneration.
HSF1A also interacts with components of the TRiC/CCT complex.

物理化学性质&存储条件

分子量	409.522
分子式	C21H19N3O2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-ethyl-N-(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-5-yl)benzenesulfonamide

参考文献

1. Neef DW, et al. PLoS Biol. 2010 Jan 19;8(1):e1000291.

2. Bocchini CE, et al. Blood. 2016 Dec 29;128(26):3061-3072.

3. Huang CY, et al. Cell Death Dis. 2016 Nov 3;7(11):e2455.

HSF1A (HSF1 activator)

生物&药学活性

物理化学性质&存储条件

参考文献

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HSF1A (HSF1 activator)

生物&药学活性

物理化学性质&存储条件

参考文献

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