HSD-016 (HSD016) | 11β-HSD1 inhibitor | Probechem Biochemicals

Chemical Structure : HSD-016

CAS No.: 946396-92-5

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HSD-016 (HSD016, HSD 016)

货号: PC-35574Not For Human Use, Lab Use Only.

HSD-016 (HSD016) is a potent, selective, and efficacious 11β-HSD1 inhibitor with IC50 of 149 and 530 nM for mouse and human 11β-HSD1, respectively.

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5 mg	￥2780	In stock
10 mg	￥4580	In stock
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生物&药学活性

HSD-016 (HSD016) is a potent, selective, and efficacious 11β-HSD1 inhibitor with IC50 of 149 and 530 nM for mouse and human 11β-HSD1, respectively.
HSD-016 significantly inhibits the 11β-HSD1 activity in mice 3T3-L1 adipocytes with IC50 of 362 nM.
HSD-016 (HSD016) has entered phase I clinical trials for the treatment of diabetes.

物理化学性质&存储条件

分子量	514.459
分子式	C21H21F7N2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1,1,1-trifluoro-2-(3-((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-ylsulfonyl)phenyl)propan-2-ol

参考文献

1. Wan ZK, et al. J Org Chem. 2011 Sep 2;76(17):7048-55.

2. Hong SP, et al. Eur J Pharmacol. 2018 Aug 7. pii: S0014-2999(18)30450-3.

HSD-016 (HSD016, HSD 016)

生物&药学活性

物理化学性质&存储条件

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HSD-016 (HSD016, HSD 016)

生物&药学活性

物理化学性质&存储条件

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