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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Other Viruses-HS83128
HS83128

Chemical Structure : HS83128

CAS No.:

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HS83128

货号: PC-24294Not For Human Use, Lab Use Only.

HS83128 is a potent, hepato-selective inhibitor of hepatitis A virus (HAV), inhibits host cell TENT4A/B terminal nucleotidyltransferases required for efficient HAV RNA synthesis (IC50=6-25 nM), and potent antiviral activity against HAV in cell culture (EC50=0.6 nM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

HS83128 is a potent, hepato-selective inhibitor of hepatitis A virus (HAV), inhibits host cell TENT4A/B terminal nucleotidyltransferases required for efficient HAV RNA synthesis (IC50=6-25 nM), and potent antiviral activity against HAV in cell culture (EC50=0.6 nM).

物理化学性质&存储条件

分子量 513.63
分子式 C29H39NO7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-9-((8-carboxy-7,7-dimethyloctyl)oxy)-6-isopropyl-10-methoxy-2-oxo-6,7-dihydro-2H-pyrido[2,1-a]isoquinoline-3-carboxylic acid

参考文献

1. Misumi I, et al. Antiviral Res. 2025 Mar 19:106145.

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