HS56 |CAS:922050-57-5 Probechem Biochemicals

Chemical Structure : HS56

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HS56 (Pim-DAPK3 inhibitor HS56)

货号: PC-35492Not For Human Use, Lab Use Only.

HS56 (Pim-DAPK3 inhibitor HS56) is a potent, dual Pim/DAPK3 inhibitor with Ki of 72 nM (Pim-3) and 315 nM (DAPK3), shows micromolar potency toward Pim-1 and Pim-2 (Ki=1.5 and 17 uM).

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生物&药学活性

HS56 (Pim-DAPK3 inhibitor HS56) is a potent, dual Pim/DAPK3 inhibitor with Ki of 72 nM (Pim-3) and 315 nM (DAPK3), shows micromolar potency toward Pim-1 and Pim-2 (Ki=1.5 and 17 uM).
HS56 displays a high degree of selectivity for DAPKs and Pims against a panel of 468 kinases, with only two off-target interactions TYK2 and GAK.
HS56 also displays no significant inhibition or activation of nicotinic, adrenergic, or muscarinic receptors at 10 uM.
HS56 delayed force onset, decreased contractile force, and reduced LC20 phosphorylation in excised rat caudal arterial VSM tissues.
HS56 lowers blood pressure in spontaneously hypertensive mice without affecting heart rate.

物理化学性质&存储条件

分子量	317.751
分子式	C13H8ClN5OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((1-(3-chlorophenyl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)thio)acetonitrile

参考文献

1. Carlson DA, et al. Cell Chem Biol. 2018 Jul 4. pii: S2451-9456(18)30220-4.

HS56 (Pim-DAPK3 inhibitor HS56)

生物&药学活性

物理化学性质&存储条件

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HS56 (Pim-DAPK3 inhibitor HS56)

生物&药学活性

物理化学性质&存储条件

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