HS-72 | Hsp70i inhibitor | Probechem Biochemicals

Chemical Structure : HS-72

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HS-72 (HS72)

货号: PC-62650Not For Human Use, Lab Use Only.

HS-72 is an allosteric, selective, cell-permeable inhibitor of inducible Hsp70 (Hsp70i or Hsp72), shows selectivity for Hsp70i over the closely related Hsc70 as well as the broader purinome.

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生物&药学活性

HS-72 is an allosteric, selective, cell-permeable inhibitor of inducible Hsp70 (Hsp70i or Hsp72), shows selectivity for Hsp70i over the closely related Hsc70 as well as the broader purinome.
HS-72 inhibits Hsp70i activity in a Huntington’s cell model and across multiple tumorigenic cell lines.
HS-72 causes degradation of HER2 and Akt.
HS-72 is bioavailable in vivo and reduces tumor growth in a spontaneous mouse mammary tumor model; also demonstrates anti-dengue virus activity.

物理化学性质&存储条件

分子量	364.44
分子式	C20H24N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(1-propyl-1H-benzo[d]imidazol-2-yl)-1-(pyrazin-2-yl)piperidine-3-carboxamide

参考文献

1. Howe MK, et al. Chem Biol. 2014 Dec 18;21(12):1648-59.

2. Howe MK, et al. Antiviral Res. 2016 Jun;130:81-92.

HS-72 (HS72)

生物&药学活性

物理化学性质&存储条件

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HS-72 (HS72)

生物&药学活性

物理化学性质&存储条件

参考文献

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