HS-38 |CAS:1030203-81-6 Probechem Biochemicals

Chemical Structure : HS-38

CAS No.: 1030203-81-6

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HS-38 (HS38)

货号: PC-62870Not For Human Use, Lab Use Only.

HS-38 is a potent and selective DAPK1 and DAPK3 (ZIPK) inhibitor with IC50 of 200 nM for DAPK1 and Kd of 280 nM for ZIPK.

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10 mg	￥1280	In stock
25 mg	￥1880	In stock
50 mg	￥2780	In stock
100 mg		Get quote

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生物&药学活性

HS-38 is a potent and selective DAPK1 and DAPK3 (ZIPK) inhibitor with IC50 of 200 nM for DAPK1 and Kd of 280 nM for ZIPK.
HS-38 also inhibits Pim3 (IC50=200 nM), and displays no activity against Src or Abl, little activity against EGFR.
HS-38 decreases RLC20 phosphorylation in cells, and decreases contractile force generated in mouse aorta, rabbit ileum, and calyculin A stimulated arterial muscle by decreasing RLC20 and MYPT1 phosphorylation.
HS-38 also promotes relaxation in Ca(2+)-sensitized vessels.

物理化学性质&存储条件

分子量	349.793
分子式	C14H12ClN5O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[[1-(3-Chlorophenyl)-4,5-dihydro-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio]propanamide

参考文献

1. Carlson DA, et al. ACS Chem Biol. 2013 Dec 20;8(12):2715-23.

2. MacDonald JA, et al. Mol Pharmacol. 2016 Jan;89(1):105-17.

HS-38 (HS38)

生物&药学活性

物理化学性质&存储条件

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HS-38 (HS38)

生物&药学活性

物理化学性质&存储条件

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