HS-152 (HS152) | SMURF1 inhibitor | Probechem Biochemicals

Chemical Structure : HS-152

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HS-152 (HS152, HS 152)

货号: PC-35913Not For Human Use, Lab Use Only.

HS-152 (HS152) is a specific small-molecule inhibitor of SMAD ubiquitin regulatory factor 1 (SMURF1), not only potently inhibits SMURF1-mediated RHOB degradation with IC50 of 3.2 uM, but also strongly blocks SMURF1-mediated RHOA and SMAD1 degradation (IC50 4.4 uM and 2.1 uM, respectively).

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生物&药学活性

HS-152 (HS152) is a specific small-molecule inhibitor of SMAD ubiquitin regulatory factor 1 (SMURF1), not only potently inhibits SMURF1-mediated RHOB degradation with IC50 of 3.2 uM, but also strongly blocks SMURF1-mediated RHOA and SMAD1 degradation (IC50 4.4 uM and 2.1 uM, respectively).
HS-152 inhibits both SMURF1 and SMURF2 catalytic activities, effectively inhibits protrusive activity in HEK293T cells.
HS-152 blocks TGFβ-induced epithelial-mesenchymal transition (EMT) in MDCK cells, similar to the effects on these processes caused by SMURF1 loss.

物理化学性质&存储条件

分子量	400.863
分子式	C20H21ClN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-chloro-N-((3-(4-methylpiperazine-1-carbonyl) phenyl) carbamoyl)-benzamide

参考文献

1. Tian M, et al. J Biol Chem. 2019 Feb 22;294(8):2880-2891.

HS-152 (HS152, HS 152)

生物&药学活性

物理化学性质&存储条件

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HS-152 (HS152, HS 152)

生物&药学活性

物理化学性质&存储条件

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