HS-1371 |CAS:2158197-70-5 Probechem Biochemicals

Chemical Structure : HS-1371

CAS No.: 2158197-70-5

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HS-1371 (HS1371;HS 1371)

货号: PC-35704Not For Human Use, Lab Use Only.

HS-1371 (HS1371) is a novel potent, ATP-competitive receptor-interacting protein kinase-3 (RIP3 or RIPK3 kinase) inhibitor with IC50 of 20.8 nM.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
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100 mg		Get quote

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生物&药学活性

HS-1371 (HS1371) is a novel potent, ATP-competitive receptor-interacting protein kinase-3 (RIP3 or RIPK3 kinase) inhibitor with IC50 of 20.8 nM.
HS-1371 binds to the ATP binding pocket of RIP3 and inhibits ATP binding to prevent RIP3 enzymatic activity in vitro.
HS-1371 inhibits S227 auto-phosphorylation of RIP3 in treated HT-29 cells, blocks necrosome complex formation, rescues cells from RIP3-dependent necroptotic cell death but not apoptotic cell death.

物理化学性质&存储条件

分子量	384.483
分子式	C24H24N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(1-(Piperidin-4-yl)-1H-pyrazol-4-yl)-4-(p-tolyloxy)quinoline

参考文献

1. Park HH, et al. Exp Mol Med. 2018 Sep 20;50(9):125.

HS-1371 (HS1371;HS 1371)

生物&药学活性

物理化学性质&存储条件

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HS-1371 (HS1371;HS 1371)

生物&药学活性

物理化学性质&存储条件

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