HR488B | HDAC1 inhibitor | Probechem Biochemicals

Chemical Structure : HR488B

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HR488B (HR 488B)

货号: PC-21537Not For Human Use, Lab Use Only.

HR488B is a potent, selective HDAC1 inhibitor with IC50 of 1.24 uM, effectively inhibits the proliferation of CRC cells.

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生物&药学活性

HR488B is a potent, selective HDAC1 inhibitor with IC50 of 1.24 uM, effectively inhibits the proliferation of CRC cells.
HR488B exhibits a substantially stronger inhibitory effect against HCT116 (IC50 = 0.17 μM) and HT29 (IC50 = 0.59 μM) than SAHA (IC50 = 2.13 μM).
HR488B exhibits good selectivity against HDAC1 over HDAC2 (IC50 = 1.24 nM against HDAC1, IC50 = 10.42 nM against HDAC2), and shows low activity against HDAC8 (IC50 > 10 μM) and HDAC6 (IC50 > 10 μM).
HR488B (10 mg/kg/d) significantly suppresses the tumor growth in an HCT116 xenograft model.

物理化学性质&存储条件

分子量	488.00
分子式	C24H26ClN3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-((4-(2-chlorophenyl)thiazol-2-yl)methyl)-N7-hydroxy-N1-(4-methoxyphenyl)heptanediamide

参考文献

1. Namin Duan, et al. Cell Death Dis. 2023 Dec 7;14(12):801.

HR488B (HR 488B)

生物&药学活性

物理化学性质&存储条件

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HR488B (HR 488B)

生物&药学活性

物理化学性质&存储条件

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