HR3744 | SaeR inhibitor | Probechem Biochemicals

Chemical Structure : HR3744

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HR3744 (HR 3744)

货号: PC-21136Not For Human Use, Lab Use Only.

HR3744 is a selective small molecule inhibitor of S. aureus exoprotein expression regulator (SaeR) withEC50 of 10 uM in saeP1 promoter assays, reduces expression of hla and other virulence factors.

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生物&药学活性

HR3744 is a selective small molecule inhibitor of S. aureus exoprotein expression regulator (SaeR) withEC50 of 4.2 uM in luciferase assays, reduces expression of hla and other virulence factors.
HR3744 interacts with the amino acid E159 of SaeR protein.
HR3744 supresses S. aureus pathogenesis by inhibiting the expression of virulence factors without any killing effect.
HR3744 demonstrates in vivo effectiveness against S. aureus infection in mice.

物理化学性质&存储条件

分子量	465.27
分子式	C18H13BrN2O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-[[3-Bromo-4-[[(4-methylphenyl)sulfonyl]oxy]phenyl]methylene]-2,4,6(1H,3H,5H)-pyrimidinetrione

参考文献

1. Peng Gao, et al. Emerg Microbes Infect. 2023 Sep 6;2254415.

HR3744 (HR 3744)

生物&药学活性

物理化学性质&存储条件

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HR3744 (HR 3744)

生物&药学活性

物理化学性质&存储条件

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