HR22C16 |CAS:462630-41-7 Probechem Biochemicals

Chemical Structure : HR22C16

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HR22C16 (trans-HR22C16, Monastroline)

货号: PC-70047Not For Human Use, Lab Use Only.

HR22C16 (Monastroline) is a potent, selective and cell permeable inhibitor of mitotic kinesin Eg5 with IC50 of 0.8 uM, does not interact with other microtubule motor proteins.

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生物&药学活性

HR22C16 (Monastroline) is a potent, selective and cell permeable inhibitor of mitotic kinesin Eg5 with IC50 of 0.8 uM, does not interact with other microtubule motor proteins.
HR22C16 (Monastroline) inhibits cell survival in both Taxol-sensitive and -resistant ovarian cancer cells with at least 15-fold greater efficacy than monastrol.

物理化学性质&存储条件

分子量	389.455
分子式	C23H23N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-butyl-5-(3-hydroxyphenyl)-5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione

参考文献

1. Hotha S, et al. Angew Chem Int Ed Engl. 2003 May 30;42(21):2379-82.

2. Marcus AI, et al. J Biol Chem. 2005 Mar 25;280(12):11569-77.

HR22C16 (trans-HR22C16, Monastroline)

生物&药学活性

物理化学性质&存储条件

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HR22C16 (trans-HR22C16, Monastroline)

生物&药学活性

物理化学性质&存储条件

参考文献

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