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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-HQY1428
HQY1428

Chemical Structure : HQY1428

CAS No.: 3093763-71-1

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HQY1428 (HQY-1428)

货号: PC-26145Not For Human Use, Lab Use Only.

HQY1428 is an oral availabile cyclin K molecular glue degrader, promotes CDK12 condensation in nuclear speckles and accelerates proteasomal degradation of CDK12-cyclin K, shows potent single-agent antitumor activity and synergistic efficacy with HER2 inhibitors.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

HQY1428 is an oral availabile cyclin K molecular glue degrader, promotes CDK12 condensation in nuclear speckles and accelerates proteasomal degradation of CDK12-cyclin K, shows potent single-agent antitumor activity and synergistic efficacy with HER2 inhibitors.

物理化学性质&存储条件

分子量 547.05
分子式 C25H28ClFN6O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-(3-amino-5-fluorophenyl)(3-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)piperidin-1-yl)methanone

参考文献

1. Ye K, et al. bioRxiv, 2025: 2025.03. 31.646293.

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