HPK inhibitor compound 1

Chemical Structure : HPK inhibitor compound 1

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货号: PC-38665Not For Human Use, Lab Use Only.

HPK inhibitor compound 1 is an allosteric, inactive conformation-selective HPK1 inhibitor, binds to unphosphorylated HPK1 and >24-fold more potently than active HPK1.

规格	价格	库存	数量
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25 mg		Get quote
100 mg		Get quote

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生物&药学活性

HPK inhibitor compound 1 is an allosteric, inactive conformation-selective HPK1 inhibitor, binds to unphosphorylated HPK1 and >24-fold more potently than active HPK1.
HPK inhibitor compound 1 is not competitive with ATP, and is highly selective against kinases critical for T cell signaling.
HPK inhibitor compound 1 does not bind to the isolated HPK1 kinase domain alone but requires other domains, attenuates kinase autophosphorylation by binding to a pocket consisting of residues within and outside of the kinase domain.

物理化学性质&存储条件

分子量	412.443
分子式	C19H17FN6O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3,7-dimethyl-5-oxo-5,8-dihydro-[1,2,4]triazolo[4,3-a]pyrimidin-6-yl)-N-(5-(3-fluorobenzyl)thiazol-2-yl)acetamide

参考文献

1. Weixue Wang, et al. Biochemistry. 2021 Oct 19;60(41):3114-3124.