HPK1 inhibitor CompK | HPK1 (MAP4K1) inhibitor | Probechem Biochemicals

Chemical Structure : HPK1 inhibitor CompK

CAS No.: 2320462-65-3

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HPK1 inhibitor CompK (HPK1-IN-7, Compound K)

货号: PC-72055Not For Human Use, Lab Use Only.

Compound K (HPK1 inhibitor CompK) is a novel, potent, highly selective HPK1 (MAP4K1) kinase inhibitor with IC50 of 2.6 nM, 50-fold selectivity against other members of the MAP4K family.

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5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg	￥5880	In stock
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100 mg		Get quote

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生物&药学活性

HPK1 inhibitor CompK (HPK1-IN-7) is a novel, potent, highly selective HPK1 (MAP4K1) kinase inhibitor with IC50 of 2.6 nM, 50-fold selectivity against other members of the MAP4K family.
Compound K enhanced IFN-γ production in human CD8+ T cells with EC50 of 137 nM, showed potential benefit in restoring T-cell polyfunctionality under immunosuppressive conditions relevant to the TME.
CompK treatment demonstrated markedly enhanced human T-cell immune responses under immunosuppressive conditions relevant to the TME and an increased avidity of the T-cell receptor (TCR) to recognize viral and tumor-associated antigens (TAAs) in significant synergy with anti-PD1.
Animal model studies, revealed improved immune responses and superb antitumor efficacy in combination of CompK with anti-PD-1.

物理化学性质&存储条件

分子量	458.478
分子式	C24H22N6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1(3H)-Isobenzofuranone, 5-[[4-[[(1S)-2-hydroxy-1-phenylethyl]amino]-5-(1,3,4-oxadiazol-2-yl)-2-pyrimidinyl]amino]-3,3-dimethyl-

参考文献

1. Dan You, et al. J Immunother Cancer. 2021 Jan;9(1):e001402.

HPK1 inhibitor CompK (HPK1-IN-7, Compound K)

生物&药学活性

物理化学性质&存储条件

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HPK1 inhibitor CompK (HPK1-IN-7, Compound K)

生物&药学活性

物理化学性质&存储条件

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