HPK1 inhibitor 1

Chemical Structure : HPK1 inhibitor 1

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货号: PC-72013Not For Human Use, Lab Use Only.

HPK1 inhibitor 1 is a highly potent, selective inhibitor of HPK1/MAP4K1 with biochemical IC50 of 0.0465 nM.

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100 mg		Get quote

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生物&药学活性

HPK1 inhibitor 1 is a highly potent, selective inhibitor of HPK1/MAP4K1 with biochemical IC50 of 0.0465 nM.
HPK1 inhibitor 1 displays >100-fold selectivity against 260 kinases in a panel of 265 kinases.
HPK1 inhibitor 1 decreased SLP-76 phosphorylation in a human pSLP-76 ELISA at an IC50 lower than 0.02 uM.
HPK1 inhibitor 1 enhanced Th1 cytokine production in T cells and fully reverted immune suppression imposed by the prostaglandin E2 (PGE2) and adenosine pathways in human T cells.
HPK1 inhibitor 1 demonstrated a synergistic effect, resulting in enhanced interferon (IFN)-γ production when combination with pembrolizumab in human PBMCs

物理化学性质&存储条件

分子量	474.544
分子式	C25H27FN8O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((8-amino-6-(5-amino-4-methylpyridin-3-yl)-7-fluoroisoquinolin-3-yl)amino)-6-isopropyl-5,6-dihydro-4H-pyrazolo[1,5-d][1,4]diazepin-7(8H)-one

参考文献

1. Brian M Lacey, et al. SLAS Discov. 2021 Jan;26(1):88-99.

2. Yun Wang, et al. PLoS One. 2020 Dec 3;15(12):e0243145.

HPK1 inhibitor 1

生物&药学活性

物理化学性质&存储条件

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HPK1 inhibitor 1

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