HOIPIN-8 | HOIP inhibitor, LUBAC inhibitor| Probechem Biochemicals

Chemical Structure : HOIPIN-8

CAS No.: 2519537-70-1

加入收藏

HOIPIN-8 (HOIP inhibitor-8)

货号: PC-35959Not For Human Use, Lab Use Only.

HOIPIN-8 (HOIP inhibitor-8) is a potent chemical inhibitor of linear ubiquitin chain assembly complex (LUBAC, IC50=11 nM), specifically generates Met1-linked linear ubiquitin chains through the ubiquitin ligase activity in HOIP, and activates the NF-kB pathway.

规格	价格	库存
2 mg	￥1480	In stock
5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

HOIPIN-8 (HOIP inhibitor-8) is a potent chemical inhibitor of linear ubiquitin chain assembly complex (LUBAC, IC50=11 nM), specifically generates Met1-linked linear ubiquitin chains through the ubiquitin ligase activity in HOIP, and activates the NF-kB pathway.
HOIPIN-8 suppresses the linear ubiquitination activity by recombinant LUBAC, displays 255-fold increased potency over that of HOIPIN-1 (JTP-0819958, IC50=2.8 uM).
HOIPIN-8 also shows 10-fold and 4-fold enhanced inhibitory activities on LUBAC- and TNF-a-induced NF-kB activation respectively, without cytotoxicity.
HOIPIN-8 is a powerful tool to explore the physiological functions of LUBAC.

物理化学性质&存储条件

分子量	456.385
分子式	C23H15F2N4NaO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Sodium 2-(3-(2,6-difluoro-4-(1H-pyrazol-4-yl)phenyl)-3-oxoprop-1-en-1-yl)-4-(1-methyl-1H-pyrazol-4-yl)benzoate

参考文献

1. Katsuya K, et al. Biochem Biophys Res Commun. 2019 Jan 2. pii: S0006-291X(18)32846-8.

HOIPIN-8 (HOIP inhibitor-8)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

HOIPIN-8 (HOIP inhibitor-8)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.