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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-E3 Ubiquitin Ligase-HOIPIN-1
HOIPIN-1

Chemical Structure : HOIPIN-1

CAS No.:

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HOIPIN-1 (JTP-0819958;HOIP inhibitor-1)

货号: PC-35958Not For Human Use, Lab Use Only.

HOIPIN-1 (JTP-0819958, HOIP inhibitor-1) is a chemical inhibitor of linear ubiquitin chain assembly complex (LUBAC, IC50=2.8 uM), specifically generates Met1-linked linear ubiquitin chains through the ubiquitin ligase activity in HOIP, and activates the NF-kB pathway..

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10 mg ￥1280 In stock
25 mg ￥1980 In stock
50 mg ￥3180 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

HOIPIN-1 (JTP-0819958, HOIP inhibitor-1) is a chemical inhibitor of linear ubiquitin chain assembly complex (LUBAC, IC50=2.8 uM), specifically generates Met1-linked linear ubiquitin chains through the ubiquitin ligase activity in HOIP, and activates the NF-kB pathway.

物理化学性质&存储条件

分子量 304.277
分子式 C17H13NaO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Sodium (E)-2-(3-(2-methoxyphenyl)-3-oxoprop-1-en-1-yl)benzoate

参考文献

1. Katsuya K, et al. Biochem Biophys Res Commun. 2019 Jan 2. pii: S0006-291X(18)32846-8.

2. Katsuya K, et al. SLAS Discov. 2018 Dec;23(10):1018-1029.

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