HNPMI

Chemical Structure : HNPMI

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货号: PC-20818Not For Human Use, Lab Use Only.

HNPMI is a small molecule inhibitor of epidermal growth factor receptor (EGFR) with the anticancer potential against various cancers.

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1 g		Get quote

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生物&药学活性

HNPMI is a small molecule inhibitor of epidermal growth factor receptor (EGFR) with the anticancer potential against various cancers.
HNPMI significantly reduced the cell proliferation of MCF-7 and SkBr3 cells, without affecting non-cancerous cells, H9C2.
HNPMI induces G0/G1 phase arrest in CRC cells.
HNPMI altered several apoptotic-related proteins including Caspase 3, BCL-2, and p53.
HNPMI significantly downregulated the crucial proteins associated with oncogenesis in CRC cells.
HNPMI reduced tumor volume in xenograft mice.

物理化学性质&存储条件

分子量	360.41
分子式	C22H20N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	CC1=CC=C(C(N2CCC3=C2C=CC=C3)C4=CC([N+]([O-])=O)=CC=C4O)C=C1

参考文献

1. Kandhavelu J, et al. Br J Pharmacol. 2023 May 15. doi: 10.1111/bph.16141.

HNPMI

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HNPMI

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