HMN-176 | PLK1 inhibitor | Probechem Biochemicals

Chemical Structure : HMN-176

CAS No.: 173529-10-7

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HMN-176 (HMN176)

货号: PC-24098Not For Human Use, Lab Use Only.

HMN-176 is an active metabolite of HMN-214 and inhibitor of mitosis, interferes with the subcellular spatial location of PLK1, does not inhibit PLK directly.

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5 mg	￥480	In stock
10 mg	￥680	In stock
25 mg	￥1080	In stock
50 mg	￥1680	In stock
100 mg		Get quote

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生物&药学活性

HMN-176 is an active metabolite of HMN-214 and inhibitor of mitosis, interferes with the subcellular spatial location of PLK1, does not inhibit PLK directly.
HMN-176 inhibits meiotic spindle assembly in surf clam oocytes and delays satisfaction of the spindle assembly checkpoint in human somatic cells by inducing the formation of short and/or multipolar spindles.
HMN-176 (2.5 μM) greatly increases the duration of mitosis in hTERT-RPE1 and CFPAC-1 cell lines. HMN-176 displays similar cytotoxicity against tumors with various characteristics from different organs.

物理化学性质&存储条件

分子量	382.43
分子式	C20H18N2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-4-(2-((4-Methoxyphenyl)sulfonamido)styryl)pyridine 1-oxide

参考文献

1. DiMaio MA, et al. Mol Cancer Ther. 2009 Mar;8(3):592-601.

2. Tanaka H, et al. Cancer Res. 2003 Oct 15;63(20):6942-7.

HMN-176 (HMN176)

生物&药学活性

物理化学性质&存储条件

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HMN-176 (HMN176)

生物&药学活性

物理化学性质&存储条件

参考文献

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