HMGCS1 inhibitor CNP7

Chemical Structure : HMGCS1 inhibitor CNP7

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货号: PC-26814Not For Human Use, Lab Use Only.

CNP7 is a potent, selective, covalent HMG-CoA synthase 1 (HMGCS1) inhibitor, reduces HMG-CoA levels and global protein prenylation.

规格	价格	库存	数量
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250 mg		Get quote

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生物&药学活性

CNP7 is a potent, selective, covalent HMG-CoA synthase 1 (HMGCS1) inhibitor, reduces HMG-CoA levels and global protein prenylation.
CNP7 engages the catalytic cysteine Cys129 within HMGCS1′s hydrophobic pocket.
CNP7 (5 uM) reduces cellular HMG-CoA levels and global protein prenylation in HCT116 cells.
CNP7 (5 uM) inhibits cell proliferation by disrupting geranylgeranyl pyrophosphate metabolism in HCT116 cells.

物理化学性质&存储条件

分子量	386.46
分子式	C23H22N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-cyano-N-((3'-(prop-2-yn-1-ylcarbamoyl)-[1,1'-biphenyl]-3-yl)methyl)pyrrolidine-3-carboxamide

参考文献

1. Sun L, et al. J Am Chem Soc. 2026 May 13. doi: 10.1021/jacs.6c02556.