HM2-16F

Chemical Structure : HM2-16F

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货号: PC-28618Not For Human Use, Lab Use Only.

HM2-16F is an anti-tubercular inhibitor with bactericidal properties that inhibiting cytochrome bd oxidase (Cyt-bd), inhibits the growth of bedaquiline-resistant mutants, weakly inhibits F1Fo-ATP synthase, depletes ATP, and affects the entry of acetyl-CoA into the Krebs cycle, synergizes with the cytochrome bcc-aa3 oxidase inhibitor Q203 (Telacebec).

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生物&药学活性

HM2-16F is an anti-tubercular inhibitor with bactericidal properties that inhibiting cytochrome bd oxidase (Cyt-bd), inhibits the growth of bedaquiline-resistant mutants, weakly inhibits F1Fo-ATP synthase, depletes ATP, and affects the entry of acetyl-CoA into the Krebs cycle, synergizes with the cytochrome bcc-aa3 oxidase inhibitor Q203 (Telacebec).

物理化学性质&存储条件

分子量	311.31
分子式	C14H13N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3,5-diamino-6-(benzofuran-2-yl)-N-carbamimidoylpyrazine-2-carboxamide

参考文献

1. Islam MI, et al. J Bacteriol. 2021 Oct 25;203(22):e0036721.

2. Hards K, et al. Commun Biol. 2022 Feb 24;5(1):166.

HM2-16F

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物理化学性质&存储条件

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HM2-16F

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物理化学性质&存储条件

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