HLY-78 |CAS:854847-61-3 Probechem Biochemicals

Chemical Structure : HLY-78

CAS No.: 854847-61-3

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HLY-78 (HLY78;HLY 78)

货号: PC-60196Not For Human Use, Lab Use Only.

HLY-78 is a small molecule activator of the Wnt/β-catenin signaling pathway that targets the DIX domain of Axin.

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5 mg	￥1180	In stock
10 mg	￥1880	In stock
25 mg	￥2980	In stock
50 mg	￥4880	In stock
100 mg		Get quote

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生物&药学活性

HLY-78 is a small molecule activator of the Wnt/β-catenin signaling pathway that targets the DIX domain of Axin.
HLY-78 potentiates the Axin-LRP6 association, thus promoting LRP6 phosphorylation and Wnt signaling transduction.
HLY-78 acts synergistically with Wnt in the embryonic development of zebrafish and increases the expression of the conserved hematopoietic stem cell (HSC) markers, runx1 and cmyb, in zebrafish embryos.

物理化学性质&存储条件

分子量	267.3
分子式	C17H17NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine

参考文献

1. Wang S, et al. Nat Chem Biol. 2013 Sep;9(9):579-85.

2. Chen DZ, et al. J Nat Prod. 2016 Jan 22;79(1):180-8.

3. Guo X, et al. Oncol Res. 2017 May 24;25(5):799-808.

HLY-78 (HLY78;HLY 78)

生物&药学活性

物理化学性质&存储条件

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HLY-78 (HLY78;HLY 78)

生物&药学活性

物理化学性质&存储条件

参考文献

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