HLQ2H | Hsp110-STAT3 inhibitor | Probechem Biochemicals

Chemical Structure : HLQ2H

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HLQ2H (Hsp110-STAT3 inhibitor compound 6, Msi3 inhibitor 2H)

货号: PC-20807Not For Human Use, Lab Use Only.

HLQ2H (Msi3 inhibitor 2H) is a first-in-class, specific inhibitor of fungal Hsp110 molecular chaperone Msi3, inhibits the holdase activity of Msi3 (IC50=5.02 uM) as well as the growth and viability of C. albicans.

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生物&药学活性

HLQ2H (Hsp110-STAT3 inhibitor compound 6) is a first-in-class, specific inhibitor of fungal Hsp110 molecular chaperone Msi3, inhibits the holdase activity of Msi3 (IC50=5.02 uM) as well as the growth and viability of C. albicans.
HLQ2H (Hsp110-STAT3 inhibitor compound 6) also is a potent Hsp110-STAT3 interaction inhibitor with KD value of 4.04 uM for Hsp110.
HLQ2H displays no affinity against Hsp105, the primary human Hsp110, and Ssa1, a fungal Hsp70.
HLQ2H reduces the ATP binding affinity of Msi3, shows limited impact on the NEF (nucleotide exchange factor) activity of Msi3.
HLQ2H specifically inhibits the Msi3-dependent refolding activity of the Hsp70 chaperone system.
HLQ2H effectively reduces the growth of Candida albicans (MC90=25 uM, wild-type C. albicans strain SC5314), with limited impacts on human cells.
HLQ2H effectively inhibited both in vivo protein refolding and dismantling protein aggregates.
HLQ2H induces the expression of Msi3 and related chaperones in C. albicans.

物理化学性质&存储条件

分子量	437.51
分子式	C25H23N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3-methyl-6-((3-methylbenzyl)oxy)-1-phenyl-1H-pyrazolo[3,4-b]pyridin-5-yl)pyrimidine-4,6-diamine

参考文献

1. Liqing Hu, et al. Nat Commun. 2023 May 12;14(1):2745.
2. Congke Zhao, et al. Respir Res. 2023 Nov 17;24(1):289.

HLQ2H (Hsp110-STAT3 inhibitor compound 6, Msi3 inhibitor 2H)

生物&药学活性

物理化学性质&存储条件

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HLQ2H (Hsp110-STAT3 inhibitor compound 6, Msi3 inhibitor 2H)

生物&药学活性

物理化学性质&存储条件

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