HL-43 | EP4 antagonist | Probechem Biochemicals

Chemical Structure : HL-43

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HL-43 (EP4 antagonist HL-43)

货号: PC-38004Not For Human Use, Lab Use Only.

HL-43 (EP4 antagonist HL-43) is a selective prostaglandin E receptor 4 (EP4) antagonist, promotes chondrocyte differentiation/cartilage regeneration and anabolism with low toxicity.

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生物&药学活性

HL-43 (EP4 antagonist HL-43) is a selective prostaglandin E receptor 4 (EP4) antagonist, promotes chondrocyte differentiation/cartilage regeneration and anabolism with low toxicity.
HL-43 exhibits the highest potency in inducing Col2a1 expression and reducing Mmp3 expression in presence of IL-1β.
HL-43 downregulats Mmp3/13 expression in a dose-dependent manner. HL-43 induces anabolic factors (ACAN and SOX9), and suppresses catabolic factor (MMP13), and hypertrophic marker (COLX), inhibits the STAT3 catabolic pathway.
HL-43 promotes chondrocyte differentiation and ECM generation, and inhibits matrix degradation in both human and mouse articular cartilage explants.
HL-43 enhances cartilage repair and regeneration in different artilage defect (CD) animal models.

物理化学性质&存储条件

分子量	474.492
分子式	C26H23FN4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-(1-(1-(2-(4-fluorophenoxy)ethyl)-4-phenyl-1H-1,2,3-triazole-5-carboxamido)ethyl)benzoic acid

参考文献

1. Yunyun Jin, et al. Cell Discov. 2022 Mar 8;8(1):24.

HL-43 (EP4 antagonist HL-43)

生物&药学活性

物理化学性质&存储条件

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HL-43 (EP4 antagonist HL-43)

生物&药学活性

物理化学性质&存储条件

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