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首页-小分子抑制剂&激动剂-Others-Other Targets-HKi6
HKi6

Chemical Structure : HKi6

CAS No.: 50493-59-9

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HKi6 (HEG1-KRIT1 inhibitor 6)

货号: PC-23287Not For Human Use, Lab Use Only.

HKi6 is a specific small-molecule HEG1-KRIT1 inhibitor (IC50=1.5 uM) by competing orthosterically with HEG1 for binding to the KRIT1 FERM domain, elevates KLF4 and KLF2 gene expression and increases Akt phosphorylation.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

HKi6 is a specific small-molecule HEG1-KRIT1 inhibitor (IC50=1.5 uM) by competing orthosterically with HEG1 for binding to the KRIT1 FERM domain, elevates KLF4 and KLF2 gene expression and increases Akt phosphorylation.
HKi6 (75 μM) significantly reduced the localization of EGFP‐KRIT1 to wild‐type HEG1 tail at the mitochondria, indicating that HKi6 disrupts the HEG1–KRIT1 interaction in living cells.

物理化学性质&存储条件

分子量 202.21
分子式 C12H10O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-hydroxy-6-methoxy-1-naphthaldehyde

参考文献

1. Lopez-Ramirez MA, et al. FASEB Bioadv. 2021 Feb 18;3(5):334-355.

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