HKi2 | HEG1-KRIT1 inhibitor | Probechem Biochemicals

Chemical Structure : HKi2

CAS No.: 708-06-5

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HKi2 (HEG1-KRIT1 inhibitor 2)

货号: PC-23286Not For Human Use, Lab Use Only.

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25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg	￥2980	In stock
250 mg		Get quote

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生物&药学活性

HKi2 is a specific small-molecule HEG1-KRIT1 inhibitor (IC50=3.5 uM) by competing orthosterically with HEG1 for binding to the KRIT1 FERM domain, elevates KLF4 and KLF2 gene expression and increases Akt phosphorylation.
HKi2 treatment (50 μM) leads to KLF2 and KLF4 upregulation in endothelial cells.
KRIT1 Lys720 forms a covalent reversible bond with the aldehyde of HKi2 and HKi2 does not block PARD3 binding to HEG1.
HKi2 upregulates KLF4 and KLF2 target genes in endothelial cells.
HKi2 induces expression of klf2a in arterial and venous endothelium in zebrafish.
HKi2 treatment increases Akt phosphorylation at S473 that is dependent on PI3K activity.
The transmembrane protein heart of glass1 (HEG1) directly binds to and recruits Krev interaction trapped protein 1 (KRIT1) to endothelial junctions to form the HEG1-KRIT1 protein complex that establishes and maintains junctional integrity.

物理化学性质&存储条件

分子量	172.18
分子式	C11H8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-hydroxy-1-naphthaldehyde

参考文献

1. Lopez-Ramirez MA, et al. FASEB Bioadv. 2021 Feb 18;3(5):334-355.

HKi2 (HEG1-KRIT1 inhibitor 2)

生物&药学活性

物理化学性质&存储条件

参考文献

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HKi2 (HEG1-KRIT1 inhibitor 2)

生物&药学活性

物理化学性质&存储条件

参考文献

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