HKI-357 | EGFR inhibitor | Probechem Biochemicals

Chemical Structure : HKI-357

CAS No.: 848133-17-5

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HKI-357 (HKI 357)

货号: PC-38733Not For Human Use, Lab Use Only.

HKI-357 is a potent, irreversible inhibitor of ErbB2 (HER2) and EGFR with IC50 values of 33 and 34 nM respectively.

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
50 mg	￥7280	In stock
100 mg		Get quote

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生物&药学活性

HKI-357 is a potent, irreversible inhibitor of ErbB2 (HER2) and EGFR with IC50 values of 33 and 34 nM respectively.
HKI-357 inhibits ligand-induced EGFR autophosphorylation and cell proliferation in NCI-H1975 cells containing L858R and T790M mutations.
HKI-357 demonstrate increased killing of NSCLC cells harboring an EGFR mutation, compared with cells expressing wild-type receptor.
HKI-357 is 10-fold more effective than gefitinib in suppressing EGFR autophosphorylation (measured at residue Y1068), and AKT and MAPK phosphorylation in parental NCI-H1650 cells harboring the delE746-A750 EGFR mutation.

物理化学性质&存储条件

分子量	574.05
分子式	C31H29ClFN5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2E)-N-[[4-[[(3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide

参考文献

1. Eunice L Kwak, et al. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7665-70.

HKI-357 (HKI 357)

生物&药学活性

物理化学性质&存储条件

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HKI-357 (HKI 357)

生物&药学活性

物理化学性质&存储条件

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