HJC0726 | EPAC2 inhibitor | Probechem Biochemicals

Chemical Structure : HJC0726

加入收藏

HJC0726 (HJC-0726)

货号: PC-63105Not For Human Use, Lab Use Only.

HJC0726 (HJC-0726) is a potent Exchange proteins directly activated by cAMP (EPAC) inhibitor, inhibits cAMP-mediated EPAC2 GEF activity with IC50 of 1.0 uM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

HJC0726 (HJC-0726) is a potent Exchange proteins directly activated by cAMP (EPAC) inhibitor, inhibits cAMP-mediated EPAC2 GEF activity with IC50 of 1.0 uM.
HJC0726 also inhibits EPAC1-mediated Rap1-GDP exchange activity.
HJC0726 does not alter cAMP-induced type I and II PKA holoenzymes activation at 25 uM.
HJC0726 inhibits GEF activity of the full-length EPAC1 in the presence of 20 µM cAMP with IC50 of 2.4 uM.

物理化学性质&存储条件

分子量	365.214
分子式	C16H14Cl2N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(5-(tert-butyl)isoxazol-3-yl)-N-(3,5-dichlorophenyl)-2-oxoacetohydrazonoyl cyanide

参考文献

1. Chen H, et al. J Med Chem. 2014 May 8;57(9):3651-65.

2. Chen H, et al. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4038-43.

3. Juhász T, et al. Cell Signal. 2014 Mar;26(3):468-82.

4. Zhu Y, et al. Sci Rep. 2015 Mar 20;5:9344.

HJC0726 (HJC-0726)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

HJC0726 (HJC-0726)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.