Chemical Structure : HJC0338
货号: PC-63110Not For Human Use, Lab Use Only.
HJC0338 is a potent and specific EPAC2 antagonist with IC50 of 0.4 uM for competing with 8-NBD-cAMP in binding EPAC2.
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HJC0338 is a potent and specific EPAC2 antagonist with IC50 of 0.4 uM for competing with 8-NBD-cAMP in binding EPAC2.
HJC0338 exhibits no inhibition of EPAC1-mediated Rap1-GDP exchange activity at 25 uM.
HJC0338 selectively block cAMP-induced EPAC2 activation but do not inhibit cAMP-mediated PKA activation.
分子量 | 280.192 | |
分子式 | C15H15Cl2N | |
外观性状 | Solid | |
储存条件 |
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Solubility |
10 mM in DMSO |
1. Chen H, et al. J Med Chem. 2013 Feb 14;56(3):952-62.
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