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首页-小分子抑制剂&激动剂-Others-Other Targets-HJC0197
HJC0197

Chemical Structure : HJC0197

CAS No.: 1383539-73-8

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HJC0197 (HJC-0197)

货号: PC-63108Not For Human Use, Lab Use Only.

HJC0197 is a potent Exchange proteins directly activated by cAMP (EPAC) inhibitor with IC50 of 4.0 uM.

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5 mg ￥880 In stock
10 mg ￥1380 In stock
25 mg ￥2480 In stock
50 mg ￥3980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

HJC0197 is a potent Exchange proteins directly activated by cAMP (EPAC) inhibitor with IC50 of 4.0 uM.
HJC0197 also inhibits EPAC1-mediated Rap1-GDP exchange activity.
HJC0197 does not alter cAMP-induced type I and II PKA holoenzymes activation at 25 uM.

物理化学性质&存储条件

分子量 339.457
分子式 C19H21N3OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-cyclopentyl-2-((2,5-dimethylbenzyl)thio)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

参考文献

1. Chen H, et al. J Med Chem. 2014 May 8;57(9):3651-65.

2. Chen H, et al. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4038-43.

3. Juhász T, et al. Cell Signal. 2014 Mar;26(3):468-82.

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