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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-STAT-HJC0152
HJC0152

Chemical Structure : HJC0152

CAS No.: 1420290-99-8

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HJC0152 (HJC-0152;HJC 0152)

货号: PC-60934Not For Human Use, Lab Use Only.

HJC0152 is a potent, orally bioavailable STAT3 signaling inhibitor that exhibits promising antitumor effects in vitro and in vivo via inactivating STAT3 and downstream miR-21/β-catenin axis.

规格 价格 库存 数量
5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg ￥3280 In stock
100 mg ￥5280 In stock
200 mg Get quote
1 g Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

HJC0152 is a potent, orally bioavailable STAT3 signaling inhibitor that exhibits promising antitumor effects in vitro and in vivo via inactivating STAT3 and downstream miR-21/β-catenin axis.
HJC0152 potently inhibits MCF-7, MDA-MB-231, AsPC1 and Panc-1a cell with IC50 of 0.91, 1.64, 1.9 and 1.08 uM, respectively.
HJC0152 suppresses HNSCC cell proliferation, arrests the cell cycle at the G0-G1 phase, induces apoptosis and reduces cell invasion in both SCC25 and CAL27 cell lines.
HJC0152 inhibits nuclear translocation of phosphorylated STAT3 at Tyr705 and decreases VHL/β-catenin signaling activity via regulation of miR-21。
HJC0152 suppresses MDA-MB-231 xenograft tumor growth in vivo.

物理化学性质&存储条件

分子量 406.644
分子式 C15H14Cl3N3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(2-aminoethoxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide hydrochloride

参考文献

1. Chen H, et al. ACS Med Chem Lett. 2013 Feb 14;4(2):180-185.

2. Wang Y, et al. Mol Cancer Ther. 2017 Apr;16(4):578-590.

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